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What is the Purpose for Farxiga?

 Farxiga (dapagliflozin) is an oral medication primarily used to:   1. Manage Type 2 Diabetes    Mechanism: It’s an SGLT2 (sodium-glucose cotransporter-2) inhibitor. It works by blocking glucose reabsorption in the kidneys, causing excess sugar to be excreted in urine.     Effect:  Lowers blood sugar levels, reduces HbA1c, and promotes weight loss (typically 2–4 kg).   2. Protect Heart & Kidneys (Key Long-Term Benefits)      - Heart Failure      - Approved to reduce hospitalization and death in adults with heart failure (both with and without diabetes).        - Improves heart function and symptoms like fatigue/swelling.      Chronic Kidney Disease (CKD)      - Slows kidney damage progression and lowers risk of kidney failure/dialysis in diabetic and non-diabetic CKD patients.      Cardiovascular Protection:      - Reduces risk of hear...
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What is the Purpose for Farxiga?

 Farxiga (dapagliflozin) is an oral medication primarily used to:  


1. Manage Type 2 Diabetes

   Mechanism: It’s an SGLT2 (sodium-glucose cotransporter-2) inhibitor. It works by blocking glucose reabsorption in the kidneys, causing excess sugar to be excreted in urine.  

  Effect:  Lowers blood sugar levels, reduces HbA1c, and promotes weight loss (typically 2–4 kg).  


2. Protect Heart & Kidneys (Key Long-Term Benefits)  

   - Heart Failure

     - Approved to reduce hospitalization and death in adults with heart failure (both with and without diabetes).  

     - Improves heart function and symptoms like fatigue/swelling.  

   Chronic Kidney Disease (CKD)

     - Slows kidney damage progression and lowers risk of kidney failure/dialysis in diabetic and non-diabetic CKD patients.  

   Cardiovascular Protection:

     - Reduces risk of heart attack/stroke in people with type 2 diabetes and existing heart disease.  


3. Other Approved Uses

   -Type 1 Diabetes (in some countries):  

     - Adjunct to insulin (requires careful monitoring due to DKA risk).  

   - Non-Alcoholic Fatty Liver Disease (NAFLD):

     - Emerging evidence suggests benefits for liver fat reduction (though not yet FDA-approved for this).  


Important Consideration 

Side Effects: 

  - Genital yeast infections (common).  

  - Urinary tract infections (UTIs).  

  - Diabetic Ketoacidosis (DKA):Rare but serious (monitor for symptoms like nausea, abdominal pain, confusion).  

  - Dehydration/low blood pressure.  

Who Should Avoid It?

  - People with severe kidney impairment (eGFR <25).  

  - Type 1 diabetics (unless prescribed off-label with strict safeguards).  

  - History of Fournier’s gangrene or hypersensitivity.  



How It Compares to Metformin 

- Metformin (first-line for diabetes) improves insulin sensitivity.  

- Farxiga offers -unique organ protection- (heart/kidneys) beyond glucose control.  

- Often prescribed *with* metformin for additive benefits.  


If you’re considering Farxiga for diabetes, heart failure, or kidney protection, consult your doctor to discuss suitability and monitoring. Need clarification on a specific use case?

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